The YEASTRACT+ information system (http://YEASTRACT-PLUS.org/) is a wide-scope computational tool for the analysis and prediction of transcription regulatory associations at the gene and genomic levels in 10 yeast species of biotechnological or human health relevance. A large team led by Isabel Sá-Correia, Miguel Teixeira, from iBB, and Pedro Monteiro, from INESC-ID, has just released this new web-portal in the 2020 Nucleic Acids Research Database Issue and is compromised to continue its efforts to expand this resource, which is currently supported within the context of the Biodata.pt/Elixir.pt Research Infrastructure.